Many articles have been written based on the research done at Legacy Pediatrics. Thanks to our patients and families, Legacy Pediatrics has contributed greatly to the evidence base in Pediatric medicine. You can search Drs. Casey and Pichichero’s names at for a complete listing of published articles.

JAMA pediatrics Effect of Antimicrobial Treatment of Acute Otitis Media on the Daily Disappearance of Middle Ear Effusion

Mucosal immunology Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young children

BMC Infectious DiseasesCorrelation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures

The LaryngoscopeCytokine, chemokine, and toll-like receptor expression in middle ear fluids of children with acute otitis media

International Journal of Pediatric OtorhinolaryngologyIdentification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing

Pediatric Infectious Disease JournalReducing the Frequency of Acute Otitis Media by Individualized Care

Pediatric Infectious Disease Journal  – Serum Antibody Response to Five Streptococcus pneumoniae Proteins during Acute Otitis Media in Otitis Prone and Non-Otitis Prone Children

Pediatric Infectious Disease Journal   – Acute Otitis Media Otopathogens during 2008-2010 in Rochester NY